CHEM 2062 - Organic Chemistry II
5 Credits
Is a continuation of CHEM 2061 that includes the study of IR and NMR spectroscopy, the chemistry of alkenes, alkynes, aromatic compounds, aldehydes, ketones, carboxylic acids and their derivatives, conjugate addition reactions, enolates and carbanions, amines and an introduction to some biochemical organic compounds. The lab component of the course provides the student experience with obtaining and interpreting IR spectra for reactants and products in organic reactions, synthesis and isolation products from reaction mixtures, identification methods for selected families of organic compounds and analytic techniques used in the identification of organic compounds.
Pre-Requisites CHEM 2061
Major Content Areas
IR, proton NMR and C-13 NMR spectroscopy. Synthesis and reactions of alkenes and alkynes. Aromaticity, reactions of benzene and benzene derivatives. Synthesis using substituted benzene compounds. Nomenclature, synthesis and reactions of aldehydes and ketones. Nomenclature, synthesis and reactions of carboxylic acids and derivatives of carboxylic acid. Chemistry of conjugated pi bonds and its use in cyclization through the Diels-Alder reaction. Enolates and carbanions in alkylation of malonic estr, aldol condensation reactions and Claisen condensation reactions. Nomenclature, synthesis and reactions of amines. Some common monosaccharides and their reactions, disaccharides and polysaccharides.
Learning Outcomes
Interpret simple IR, proton NMR and C-13 NMR spectra to obtain the structure of an organic compound. Devote time to understanding the structure of carboxylic acids and their derivatives (anhydrides, acid halides, esters and amides) and demonstrate how to interconvert these compounds using various nucleophilic acyl addition and substitution reactions. Gain insight into the nature of aromaticity. Understand the unique structure and stability of the aromatic system (including benzene, naphthalene, heterocyclic compounds, and aromatic cations and anions.) Gain a basic understanding of the structure, synthesis and reactions of amines such as the Hofmann elimination and Cope rearrangement. Learn the unique stability and reactions of conjugated double bonds. Alpha substitutions (enol and enolate chemistry) and condensation reactions of carbonyl compounds (aldol, Claisen, acetoacetic and malonic ester syntheses, Michael addition and Robinson annulation) will be investigated thoroughly. Students will recognize characteristics of hazardous wastes and describe safe handling, storage, and disposal appropriate for this course. Learn the structures, syntheses and reactions of various ethers and epoxides. Review the numerous synthetic pathways that lead to aldehydes and ketones and learn the various nucleophilic acyl substitutions and condensation reactions that these compounds can undergo Learn a variety of electrophilic and nucleophilic aromatic substitution reactions, understand activating/deactivating groups and have a basic discussion of organopalladium coupling reactions (Heck< Suzuki, Hiyama, etc.).
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